Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever

J Pharm Biomed Anal. 2017 May 30:139:143-147. doi: 10.1016/j.jpba.2017.02.042. Epub 2017 Feb 24.

Abstract

Glycoconjugate vaccines based on the Vi capsular polysaccharide directed against Salmonella enterica serovar Typhi are licensed or in development against typhoid fever, an important cause of morbidity and mortality in developing countries. Quantification of free polysaccharide in conjugate vaccines is an important quality control for release, to monitor vaccine stability and to ensure appropriate immune response. However, we found that existing separation methods based on size are not appropriate as free Vi non-specifically binds to unconjugated and conjugated protein. We developed a method based on free Vi separation by Capto Adhere resin and quantification by HPAEC-PAD. The method has been tested for conjugates of Vi derived from Citrobacter freundii with different carrier proteins such as CRM197, Tetanus Toxoid and Diphtheria Toxoid.

Keywords: Conjugate vaccine; Free saccharide; Quantification method; Salmonella Typhi; Vi polysaccharide.

MeSH terms

  • Chromatography, Gel / methods*
  • Chromatography, High Pressure Liquid / methods
  • Glycoconjugates / analysis*
  • Glycoconjugates / therapeutic use
  • Humans
  • Polysaccharides, Bacterial / analysis*
  • Salmonella typhi*
  • Typhoid Fever* / prevention & control
  • Typhoid-Paratyphoid Vaccines / analysis*
  • Typhoid-Paratyphoid Vaccines / therapeutic use
  • Vaccines, Conjugate / analysis
  • Vaccines, Conjugate / therapeutic use

Substances

  • Glycoconjugates
  • Polysaccharides, Bacterial
  • Typhoid-Paratyphoid Vaccines
  • Vaccines, Conjugate