1 Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada. Electronic address: sinziana.avramescu@utoronto.ca.
2 Department of Physiology, University of Toronto, Toronto, ON, Canada.
3 Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada.
4 Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada.