CD8⁺ T-cell activation by methazolamide causes methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis

Clin Exp Allergy. 2017 Jul;47(7):972-974. doi: 10.1111/cea.12919. Epub 2017 Apr 10.

Authors

Y-K Jee¹, S Kim², J-M Lee², H-S Park³, S-H Kim^{3

4}

Affiliations

¹ Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
² Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
³ Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea.
⁴ Translational Research Laboratory for Inflammatory Disease, Clinical Trial Center, Ajou University Medical Center, Suwon, South Korea.

PMID: 28295713
DOI: 10.1111/cea.12919

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / immunology
CD8-Positive T-Lymphocytes / drug effects*
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism
Disease Susceptibility
Genotype
HLA Antigens / genetics
HLA Antigens / immunology
Humans
Lymphocyte Activation / drug effects*
Lymphocyte Activation / immunology*
Methazolamide / adverse effects*
Stevens-Johnson Syndrome / diagnosis*
Stevens-Johnson Syndrome / etiology*
Stevens-Johnson Syndrome / metabolism

Substances

Autoantibodies
HLA Antigens
Methazolamide