Intracellular calcium release channels: an update

J Physiol. 2017 May 15;595(10):3041-3051. doi: 10.1113/JP272781.

Abstract

Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3 Rs) are calcium (Ca2+ ) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.

Keywords: Calcium; Diabetes mellitus; Heart failure; Hypertension; IP3R; Intracellular calcium release channels; RyR; excitation-contraction coupling.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure
  • Calcium / metabolism
  • Calcium / physiology
  • Diabetes Mellitus / metabolism
  • Heart / physiology
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors / physiology*
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology
  • Myocardium / metabolism
  • Ryanodine Receptor Calcium Release Channel / physiology*

Substances

  • Inositol 1,4,5-Trisphosphate Receptors
  • Ryanodine Receptor Calcium Release Channel
  • Calcium