Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization

Christiane S Eberhardt; Geraldine Blanchard-Rohner; Barbara Lemaître; Christophe Combescure; Véronique Othenin-Girard; Antonina Chilin; Jean Petre; Begoña Martinez de Tejada; Claire-Anne Siegrist

doi:10.1093/cid/cix046

Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization

Clin Infect Dis. 2017 Apr 15;64(8):1129-1132. doi: 10.1093/cid/cix046.

Affiliations

¹ Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.
² Department of Neonatology and Pediatric Intensive Care, Children's Hospital of Geneva, Switzerland.
³ Department of Pediatrics, Children's Hospital of Geneva, Switzerland.
⁴ Clinical Research Center, , University of Geneva, Switzerland.
⁵ Department of Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Switzerland.
⁶ BioNet-Asia Co, Ltd, Bangkok, Thailand.

Abstract

Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates.

Keywords: maternal antibodies; maternal immunization; neonates; pertussis; preterm.

Publication types

Comparative Study
Observational Study

MeSH terms

Adolescent
Adult
Antibodies, Bacterial / blood*
Female
Humans
Immunity, Maternally-Acquired*
Immunization Schedule*
Infant, Newborn
Infant, Premature*
Pertussis Vaccine / administration & dosage*
Pertussis Vaccine / immunology*
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Whooping Cough / prevention & control*
Young Adult

Substances

Antibodies, Bacterial
Pertussis Vaccine