Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

Sherif Taha; Sherif Mohammed Gamal; Mohamed Nabil; Nahla Naeem; Dalia Labib; Ibrahim Siam; Tamer Atef Gheita

doi:10.1016/j.rbre.2016.11.007

Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients

Rev Bras Reumatol Engl Ed. 2017 Mar-Apr;57(2):149-153. doi: 10.1016/j.rbre.2016.11.007. Epub 2016 Dec 14.

[Article in English, Portuguese]

Authors

Sherif Taha¹, Sherif Mohammed Gamal², Mohamed Nabil³, Nahla Naeem⁴, Dalia Labib⁵, Ibrahim Siam⁶, Tamer Atef Gheita⁴

Affiliations

¹ Cairo University, Faculty of Medicine, Chemical Pathology Department, Cairo, Egypt.
² Cairo University, Faculty of Medicine, Rheumatology Department, Cairo, Egypt. Electronic address: sherif775@hotmail.com.
³ Beni-Sweif University, Faculty of Medicine, Internal Medicine Department, Beni-Sweif, Egypt.
⁴ Cairo University, Faculty of Medicine, Rheumatology Department, Cairo, Egypt.
⁵ Cairo University, Faculty of Medicine, Neurology Department, Cairo, Egypt.
⁶ National Research Center, Internal Medicine Department, Cairo, Egypt.

PMID: 28343620
DOI: 10.1016/j.rbre.2016.11.007

Abstract

Aim: To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations.

Patients and methods: Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR).

Results: Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p<0.001] and GG [10% vs 66.7%, p<0.001]).

Conclusion: Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

Keywords: G1612A (rs10434) gene; Gene G1612A (rs10434); LES; Manifestações neuropsiquiátricas; Neuropsychiatric manifestations; Polimorfismo; Polymorphism; SLE; VEGF.

MeSH terms

Adult
Cross-Sectional Studies
Female
Gene Expression Profiling
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Lupus Vasculitis, Central Nervous System / diagnosis
Lupus Vasculitis, Central Nervous System / genetics*
Lupus Vasculitis, Central Nervous System / physiopathology
Lupus Vasculitis, Central Nervous System / psychology*
Male
Middle Aged
Pilot Projects
Polymorphism, Single Nucleotide*
Vascular Endothelial Growth Factor A / genetics*
Vascular Endothelial Growth Factor A / metabolism
Young Adult

Substances

Vascular Endothelial Growth Factor A