Rational design of a luminescent nanoprobe for hypoxia imaging in vivo via ratiometric and photoluminescence lifetime imaging microscopy

Qi Yu; Tianci Huang; Yipeng Li; Huanjie Wei; Shujuan Liu; Wei Huang; Jing Du; Qiang Zhao

doi:10.1039/c7cc00668c

Rational design of a luminescent nanoprobe for hypoxia imaging in vivo via ratiometric and photoluminescence lifetime imaging microscopy

Chem Commun (Camb). 2017 Apr 6;53(29):4144-4147. doi: 10.1039/c7cc00668c.

Authors

Qi Yu¹, Tianci Huang¹, Yipeng Li¹, Huanjie Wei¹, Shujuan Liu¹, Wei Huang², Jing Du¹, Qiang Zhao¹

Affiliations

¹ Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, P. R. China. iamsjliu@njupt.edu.cn iamqzhao@njupt.edu.cn.
² Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, P. R. China. iamsjliu@njupt.edu.cn iamqzhao@njupt.edu.cn and Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, P. R. China. wei-huang@njtech.edu.cn.

PMID: 28352914
DOI: 10.1039/c7cc00668c

Abstract

A luminescent nanoprobe has been designed for detection of oxygen. The nanoprobe exhibits high sensitivity, selectivity and excellent reversibility, and has been employed for hypoxia imaging in vitro and in vivo by ratiometric and photoluminescence lifetime imaging techniques.