The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina

Curr Genet. 1985;9(5):373-82. doi: 10.1007/BF00421608.

Abstract

Mapping and transcription studies have revealed that in Podospora anserina the causative agent of senescence, a mitochondrial plasmid (plDNA), is identical with intron 1 of the discontinuous gene for cytochrome-c-oxidase subunit 1 (COI), which is 2 kpb from the discontinuous gene for cytochrome b (Cytb). A mitochondrial mutant (ex1) devoid of the COI, but not of the Cytb gene provides longevity. A molecular model for the onset of senescence is presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Ascomycota / genetics*
  • Base Sequence
  • Cytochrome b Group / genetics*
  • DNA, Mitochondrial / genetics*
  • Electron Transport Complex IV / genetics*
  • Genes*
  • Genes, Fungal*
  • Molecular Sequence Data
  • Transcription, Genetic
  • Xylariales / genetics*

Substances

  • Cytochrome b Group
  • DNA, Mitochondrial
  • Electron Transport Complex IV