Abstract
A collection of monoclonal antibodies (MAbs) against the haemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins of parainfluenza virus type 3 (PIV3) was used for passive immunization of intracerebrally infected newborn hamsters. A significant degree of protection was obtained with MAbs against both the HN and F viral proteins, but no individual antibody conferred complete protection against disease. MAbs against different epitopes provided different degrees of protection. A MAb to the Sendai virus HN protein was found to confer protection against PIV3 brain infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Antibodies, Monoclonal / immunology
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Antibodies, Monoclonal / therapeutic use*
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Antibodies, Viral / immunology
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Antibodies, Viral / therapeutic use*
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Cricetinae
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Encephalitis / prevention & control*
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HN Protein
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Immunization, Passive*
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Mesocricetus
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Parainfluenza Virus 3, Human / immunology*
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Paramyxoviridae Infections / prevention & control*
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Respirovirus / immunology*
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Viral Envelope Proteins / immunology
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Viral Fusion Proteins / immunology
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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HN Protein
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Viral Envelope Proteins
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Viral Fusion Proteins