The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics

Curtis R Warren; Cashell E Jaquish; Chad A Cowan

doi:10.1016/j.stem.2017.03.021

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics

Cell Stem Cell. 2017 Apr 6;20(4):431-433. doi: 10.1016/j.stem.2017.03.021.

Authors

Curtis R Warren¹, Cashell E Jaquish², Chad A Cowan³

Affiliations

¹ Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
² National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20824, USA.
³ Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: chad_cowan@harvard.edu.

PMID: 28388427
DOI: 10.1016/j.stem.2017.03.021

Abstract

The National Heart, Lung, and Blood Institute's Next Generation Genetic Association Studies Consortium has used induced pluripotent stem cell technology to study the effects of common genetic variants in vitro. This issue of Cell Stem Cell and affiliated journals include several manuscripts describing the results of the consortium's efforts.

Keywords: Community Cohort Study; NHLBI; Next Generation Genetic Association Studies Consortium; cardiovascular disease; genome editing; humanity in a dish; iPSC; polygenic disease; population genetics; quantitative trait locus.

MeSH terms

Cardiovascular Diseases / pathology
Cell Differentiation
Cellular Reprogramming
Gene Expression Regulation
Genetic Variation
Genetics, Population*
Genome-Wide Association Study*
Humans
Induced Pluripotent Stem Cells / cytology
Phenotype