First case of ischemic stroke which happened during continuous intravenous infusion of rt-PA

Neurol Neurochir Pol. 2017 May-Jun;51(3):263-265. doi: 10.1016/j.pjnns.2017.03.001. Epub 2017 Mar 18.

Abstract

Catheter-directed thrombolysis (CDT) is one of the methods in the treatment of patients with acute lower limb ischemia. It is based on intrathrombus infusion of one of the thrombolytic agents. The most common complication of CDT is bleeding. We present a patient with left lower limb ischemia, treated by CDT, in which symptoms of stroke, proved to have ischemic etiology, started during continuous intra-arterial infusion of rt-PA. As the patient presented with the history of atrial fibrillation, the most probable mechanism of stroke was related to detachment of possible intra-atrial thrombus. Ischemic stroke which happened during intra-arterial thrombolysis with rt-PA has never been mentioned in literature yet and the case stands for the statement that very effective causative treatment of ischemic stroke with rt-PA is not sufficient to "prevent" ischemic stroke if used in very small doses.

Keywords: Atrial fibrillation; Limb ischemia; Recombinant tissue plasminogen activator; Stroke; Thrombolysis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Atrial Fibrillation / complications
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / diagnosis
  • Cerebral Infarction / drug therapy*
  • Fatal Outcome
  • Female
  • Humans
  • Infusions, Intra-Arterial
  • Ischemia / drug therapy*
  • Leg / blood supply*
  • Recombinant Proteins / adverse effects
  • Recombinant Proteins / therapeutic use
  • Risk Factors
  • Thromboembolism / drug therapy*
  • Thrombolytic Therapy / adverse effects*
  • Tissue Plasminogen Activator / adverse effects*
  • Tissue Plasminogen Activator / therapeutic use*

Substances

  • Recombinant Proteins
  • Tissue Plasminogen Activator