No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination

S M Moerlein; D R Hwang; M J Welch

doi:10.1016/0883-2889(88)90064-0

No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination

Int J Rad Appl Instrum A. 1988;39(5):369-72. doi: 10.1016/0883-2889(88)90064-0.

Authors

S M Moerlein¹, D R Hwang, M J Welch

Affiliation

¹ Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.

PMID: 2840411
DOI: 10.1016/0883-2889(88)90064-0

Abstract

Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135 degrees C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bromine Radioisotopes*
Copper
Isotope Labeling / methods*

Substances

Bromine Radioisotopes
Copper
cuprous chloride