Objective: To analyze the correlation between olfactory bulb(OB) volume and olfactory function in patients with posttraumatic olfactory dysfunction. Methods: Forty patients with posttraumatic olfactory dysfunction were compared with forty controls in terms of olfactory function T&T testing, OB volume assessed with magnetic resonance imaging (MRI). SPSS 17.0 software was used to analyze the data. Results: T&T olfactory testing revealed that patients with posttraumatic olfactory dysfunction had higher scores than controls(3.47±0.63 vs.1.39±0.19, t=4.317, P<0.05). Both men and women with posttraumatic olfactory dysfunction were affected by the same extent of olfactory loss(3.52±0.66 vs.3.43±0.61, t=0.896, P>0.05). Both men and women as controls were affected by the same extent of olfactory loss(1.41±0.20 vs.1.38±0.17, t=1.073, P>0.05). OB volume of left side in patients with posttraumatic olfactory dysfunction were (36.15±3.16)mm(3,) right side were (39.28±3.76)mm(3,) average OB volume were (37.55±3.42)mm(3;) OB volume of left side in controls were (81.74±5.87)mm(3,) right side were (83.58±6.13)mm(3,) average OB volume were (82.59±5.99)mm(3;) OB volumes were lower in patients with posttraumatic olfactory dysfunction as compared with controls(t value were 4.815, 4.837 and 4.825, all P<0.01). Average olfactory discriminate threshold was negatively correlated with average OB volume in posttraumatic olfactory dysfunction and controls(r value was-0.582, -0.564, both P<0.05). Average olfactory discriminate threshold was positively correlated with impairment degree in patients with posttraumatic olfactory dysfunction(r value was 0.472, P<0.05), average OB volume was negatively correlated with impairment degree in patients with posttraumatic olfactory dysfunction(r value was -0.397, P<0.05) Conclusions: The OB volumes are lower in patients with posttraumatic olfactory dysfunction as compared with controls. The OB volume is correlated with olfactory function. Impairment degree in patients with posttraumatic olfactory dysfunction is accordance with olfactory function lowering degree. Megnetic resonance imaging can be used as a supplementary diagnostic tool for patients with posttraumatic olfactory dysfunction.
目的： 分析颅脑外伤后嗅觉障碍患者嗅球体积与嗅觉功能的相关性。 方法： 选取颅脑外伤后嗅觉障碍患者(外伤后嗅觉障碍组)及无嗅觉减退的健康受试者(对照组)各40例，应用T&T嗅觉测试法检查所有受试者的嗅觉功能，并行MRI检查，测量并计算嗅球体积。以SPSS 17.0软件对数据进行统计学分析。 结果： 外伤后嗅觉障碍组T&T嗅觉识别阈分数为3.47±0.63，明显高于对照组的1.39±0.19，差异有统计学意义(t＝4.317，P<0.05)。外伤后嗅觉障碍组男女嗅觉识别阈分别为3.52±0.66、3.43±0.61，差异无统计学意义(t＝0.896，P>0.05)；对照组男女嗅觉识别阈分别为1.41±0.20、1.38±0.17，差异无统计学意义(t＝1.073，P>0.05)。外伤后嗅觉障碍组左右两侧嗅球体积、平均嗅球体积分别为(36.15±3.16)、(39.28±3.76)、(37.55±3.42)mm(3)，均小于对照组的(81.74±5.87)、(83.58±6.13)、(82.59±5.99)mm(3)，差异有统计学意义(t值分别为4.815、4.837、4.825，P值均<0.01)。外伤后嗅觉障碍组及对照组平均嗅觉识别阈与平均嗅球体积呈负相关(r值分别为-0.582，-0.564，P值均<0.05)。外伤后嗅觉障碍组平均嗅觉识别阈与颅脑外伤严重程度呈正相关(r＝0.472, P<0.05)，平均嗅球体积与颅脑外伤严重程度呈负相关(r＝-0.397，P<0.05)。 结论： 颅脑外伤后嗅觉障碍患者嗅球体积减小；嗅觉功能与嗅球体积具有相关性；颅脑外伤的严重程度与嗅觉减退的程度具有一致性；磁共振成像可作为颅脑外伤后嗅觉障碍患者的一项辅助诊断手段。.
Keywords: Megnetic resonance imaging; Olfaction disorders; Olfactory bulb; Posttraumatic.