Hemophagocytic lymphohistiocytosis with high serum levels of IL-18 and predominant lymphocyte activation in a neonate born to a mother with adult-onset Still's disease

Megumi Hashimoto; Shohei Ogata; Ayano Yamaguchi; Kota Kawada; Manabu Kenmochi; Takasuke Ebato; Keiko Nomoto; Yuki Bando; Saeko Shimodera; Hirofumi Shibata; Shintaro Ono; Manabu Nakayama; Takahiro Yasumi; Masahiro Ishii

doi:10.1016/j.clim.2017.04.007

Hemophagocytic lymphohistiocytosis with high serum levels of IL-18 and predominant lymphocyte activation in a neonate born to a mother with adult-onset Still's disease

Clin Immunol. 2017 Jul:180:95-96. doi: 10.1016/j.clim.2017.04.007. Epub 2017 Apr 25.

Authors

Affiliations

¹ Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan.
² Department of Pediatrics, Kitasato Medical Center Hospital, Kitamoto, Japan.
³ Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁴ Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
⁵ Department of Technology Development, Kazusa DNA Research Institute, Kisarazu, Japan.
⁶ Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: yasumi@kuhp.kyoto-u.ac.jp.

PMID: 28450255
DOI: 10.1016/j.clim.2017.04.007

No abstract available

Keywords: Adult-onset Still's disease; Hemophagocytic lymphohistiocytosis; Interleukin-18; Lymphocyte activation; Natural killer cell dysfunction.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Infant, Newborn
Infant, Newborn, Diseases / blood
Infant, Newborn, Diseases / etiology*
Infant, Newborn, Diseases / immunology
Interleukin-18 / blood*
Lymphocyte Activation / immunology
Lymphohistiocytosis, Hemophagocytic / blood
Lymphohistiocytosis, Hemophagocytic / etiology*
Lymphohistiocytosis, Hemophagocytic / immunology
Pregnancy
Pregnancy Complications, Hematologic*
Still's Disease, Adult-Onset / complications*

Substances

IL18 protein, human
Interleukin-18