HIV Latency Gets a New Histone Mark

Cell Host Microbe. 2017 May 10;21(5):549-550. doi: 10.1016/j.chom.2017.04.012.

Abstract

Transcriptional latency of integrated HIV-1 provirus represents a major obstacle to curing HIV. In this issue of Cell Host & Microbe, Boehm et al. (2017) identify a new lysine methyltransferase that writes a repressive histone mark associated with HIV-1 latency. The results are important for strategies to pharmacologically reverse HIV-1 latency.

MeSH terms

  • Chromatin / metabolism
  • Gene Expression Regulation, Viral
  • HIV Infections / virology
  • HIV-1 / genetics
  • HIV-1 / physiology*
  • Histone Code / genetics
  • Histone Code / physiology*
  • Histones / metabolism*
  • Humans
  • Transcription, Genetic
  • Virus Integration / genetics
  • Virus Latency / genetics
  • Virus Latency / physiology*

Substances

  • Chromatin
  • Histones