Fatal case of chikungunya and concomitant thrombotic thrombocytopenic purpura in French Guiana during air flight medical evacuation

Loïc Epelboin; Bastien Bidaud; Emilie Mosnier; Paul Le Turnier; Guillaume Vesin; Gaëlle Walter; Philippe Abboud; Stéphanie Houcke; Maïa Forgues; Gérald Egmann; Alain Stepanian; Félix Djossou

doi:10.1093/jtm/tax028

Fatal case of chikungunya and concomitant thrombotic thrombocytopenic purpura in French Guiana during air flight medical evacuation

J Travel Med. 2017 Sep 1;24(5). doi: 10.1093/jtm/tax028.

Authors

Loïc Epelboin^{1

2}, Bastien Bidaud¹, Emilie Mosnier^{1

2}, Paul Le Turnier¹, Guillaume Vesin¹, Gaëlle Walter¹, Philippe Abboud^{1

2}, Stéphanie Houcke³, Maïa Forgues⁴, Gérald Egmann⁵, Alain Stepanian^{6

7}, Félix Djossou^{1

2}

Affiliations

¹ Infectious and Tropical Diseases Unit, Centre Hospitalier Andrée Rosemon, Cayenne F-97300, French Guiana, France.
² Equipe EA 3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne F-97300, French Guiana, France.
³ Intensive Care Unit, Centre Hospitalier Andrée Rosemon, Cayenne F-97300, French Guiana, France.
⁴ Department of Internal Medicine, Centre Hospitalier Andrée Rosemon, Cayenne F-97300, French Guiana, France.
⁵ Department of Emergency, Centre Hospitalier Andrée Rosemon, Cayenne F-97300, French Guiana, France.
⁶ Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris F-75010, France.
⁷ EA3518, Institut Universitaire d'Hématologie-Hôpital Saint Louis, Université Paris Diderot, Paris F-75011, France.

PMID: 28499011
DOI: 10.1093/jtm/tax028

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy associated to severe ADAMTS13 deficiency. It has been linked to various viral infections. Among arboviruses, only Crimean-Congo haemorrhagic fever and dengue fever have been linked to this severe disease. We report the first documented case of TTP concomitant to Chikungunya virus infection.

Keywords: Chikungunya virus; French Guiana; arbovirus; in-flight medical emergency; medical evacuation; thrombotic microangiopathy; thrombotic thrombocytopenic purpura.

Publication types

Case Reports

MeSH terms

Adult
Aircraft*
Chikungunya Fever / complications
Chikungunya Fever / diagnosis*
Diagnosis, Differential
Fatal Outcome
Female
French Guiana
Humans
Purpura, Thrombotic Thrombocytopenic / complications
Purpura, Thrombotic Thrombocytopenic / diagnosis*
Travel*