Genome Organization: Cohesin on the Move

Judita Richterova; Barbora Huraiova; Juraj Gregan

doi:10.1016/j.molcel.2017.05.002

Genome Organization: Cohesin on the Move

Mol Cell. 2017 May 18;66(4):444-445. doi: 10.1016/j.molcel.2017.05.002.

Authors

Judita Richterova¹, Barbora Huraiova¹, Juraj Gregan²

Affiliations

¹ Department of Genetics, Faculty of Life Sciences, Comenius University in Bratislava, Ilkovicova 6, 84215 Bratislava, Slovakia.
² Department of Genetics, Faculty of Life Sciences, Comenius University in Bratislava, Ilkovicova 6, 84215 Bratislava, Slovakia; Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr.Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address: juraj.gregan@univie.ac.at.

PMID: 28525739
DOI: 10.1016/j.molcel.2017.05.002

Abstract

Folding of mammalian genomes into spatial domains is thought to depend on cohesin and CTCF proteins. Busslinger et al. (2017) reveal that transcription moves cohesin along DNA to CTCF-binding sites, providing insights into how cohesin and CTCF mediate chromosomal interactions by formation of chromatin loops.

MeSH terms

Cell Cycle Proteins / genetics
Chromatin*
Chromosomal Proteins, Non-Histone / genetics*
Cohesins
Genome
Humans
Repressor Proteins / genetics

Substances

Cell Cycle Proteins
Chromatin
Chromosomal Proteins, Non-Histone
Repressor Proteins