Novel Anticoagulant Agents in the Perioperative Setting

Anesthesiol Clin. 2017 Jun;35(2):305-313. doi: 10.1016/j.anclin.2017.01.016. Epub 2017 Apr 7.

Abstract

An increasing number of oral anticoagulants have become available over the past decade. Each of these agents has differing implications on both regional and neuraxial anesthetic techniques. This article describes the pharmacology, pharmacokinetics, and pharmacodynamics of the most commonly used novel oral anticoagulants (NOACs). It also outlines recent guidelines for the use of NOACs in the perioperative setting, especially with regard to neuraxial anesthesia.

Keywords: ASRA guidelines; Anticoagulation; Neuraxial anesthesia; Novel oral anticoagulants; Perioperative management; Regional anesthesia.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Anesthesia, Conduction*
  • Anesthesia, General*
  • Anticoagulants / pharmacokinetics
  • Anticoagulants / pharmacology*
  • Antithrombins / pharmacokinetics
  • Antithrombins / pharmacology
  • Factor Xa Inhibitors / pharmacokinetics
  • Factor Xa Inhibitors / pharmacology
  • Humans
  • Perioperative Care / methods*
  • Perioperative Period
  • Platelet Aggregation Inhibitors / pharmacokinetics
  • Platelet Aggregation Inhibitors / pharmacology

Substances

  • Anticoagulants
  • Antithrombins
  • Factor Xa Inhibitors
  • Platelet Aggregation Inhibitors