An Analysis of New Approaches and Drug Formulations for Treatment of Chronic Low Back Pain

Karishma Patel Bhangare; Alan D Kaye; Nebojsa Nick Knezevic; Kenneth D Candido; Richard D Urman

doi:10.1016/j.anclin.2017.01.023

An Analysis of New Approaches and Drug Formulations for Treatment of Chronic Low Back Pain

Anesthesiol Clin. 2017 Jun;35(2):341-350. doi: 10.1016/j.anclin.2017.01.023. Epub 2017 Mar 14.

Authors

Karishma Patel Bhangare¹, Alan D Kaye², Nebojsa Nick Knezevic³, Kenneth D Candido³, Richard D Urman⁴

Affiliations

¹ Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
² Department of Anesthesiology and Pain Medicine, Louisiana State University School of Medicine, LSU Health Science Center, 1542 Tulane Avenue, Room 659, New Orleans, LA 70112, USA.
³ Department of Anesthesiology and Pain Medicine, Advocate Illinois Masonic Medical Center, 836 West Wellington Avenue, Suite 4815, Chicago, IL 60657, USA.
⁴ Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: urmanr@gmail.com.

PMID: 28526154
DOI: 10.1016/j.anclin.2017.01.023

Abstract

The prevalence of chronic low back pain (CLBP) is increasing. Treatment is effective in less than 50% of patients after 1 year. This review investigates new treatments for CLBP. An extensive literature review focuses on new treatments for CLBP. Their safety and efficacy were evaluated and are described in detail in this review. The investigation identified new treatments for CLBP including chemonucleolysis, platelet-rich plasma injections, artemin, tanezumab, and stem cells. Further research and innovation are needed to implement these methods into practice and assess clinical significance. The current evidence suggests that there are promising new agents for the treatment of CLBP.

Keywords: Artemin; Chemonucleolysis; Chronic low back pain; Collagenase; Ethanol; Matrix metalloproteinases; Platelet-rich plasma injections; Stem cells; Tanezumab.

Publication types

Review

MeSH terms

Antibodies, Monoclonal, Humanized / therapeutic use
Chronic Pain / therapy*
Drug Compounding
Humans
Intervertebral Disc Chemolysis / methods*
Low Back Pain / therapy*
Platelet-Rich Plasma
Stem Cell Transplantation

Substances

Antibodies, Monoclonal, Humanized
tanezumab