Resveratrol relieves Angiostrongylus cantonensis - Induced meningoencephalitis by activating sirtuin-1

Acta Trop. 2017 Sep:173:76-84. doi: 10.1016/j.actatropica.2017.05.023. Epub 2017 May 22.

Abstract

Resveratrol, a natural herbal compound found in high levels in grapes and red wine, is frequently used as activator of sirtuin-1. This study investigated the potential function of sirtuin-1 in regulating angiostrongyliasis meningoencephalitis in resveratrol-treated mice. Mice were subjected to meningoencephalitis to study the protective effect of resveratrol against meningoencephalitis and investigate the effects of sirtuin-1 activation on brain. Results demonstrated that sirtuin-1 level decreased in mice with meningoencephalitis and significantly increased in resveratrol-treated mice. Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-γ, interleukin (IL)-5, IL-33, and tumor necrosis factor-α levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability. By contrast, the anti-inflammatory factor IL-10 was significantly increased in resveratrol-treated mice. Resveratrol treatment was partially beneficial in controlling the pathological processes of angiostrongyliasis meningoencephalitis. The results demonstrate the neuroprotective and anti-inflammatory effects of resveratrol against Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis in mice. Treatment with sirtuin-1 agonist was given within a therapeutic window after A. cantonensis infection.

Keywords: Angiostrongylus cantonensis; Meningoencephalitis; Resveratrol; Sirtuin-1.

MeSH terms

  • Angiostrongylus cantonensis*
  • Animals
  • Blood-Brain Barrier / drug effects
  • Cytokines / genetics
  • Cytokines / metabolism
  • Gene Expression Regulation / drug effects*
  • Male
  • Meningoencephalitis / drug therapy
  • Meningoencephalitis / parasitology*
  • Mice
  • Resveratrol
  • Sirtuin 1 / metabolism*
  • Stilbenes / pharmacology*
  • Strongylida Infections / drug therapy*

Substances

  • Cytokines
  • Stilbenes
  • Sirtuin 1
  • Resveratrol

Supplementary concepts

  • Angiostrongyliasis