Dominance of Metric Correlations in Two-Dimensional Neuronal Cultures Described through a Random Field Ising Model

Phys Rev Lett. 2017 May 19;118(20):208101. doi: 10.1103/PhysRevLett.118.208101. Epub 2017 May 18.

Abstract

We introduce a novel random field Ising model, grounded on experimental observations, to assess the importance of metric correlations in cortical circuits in vitro. Metric correlations arise from both the finite axonal length and the heterogeneity in the spatial arrangement of neurons. The experiments consider the response of neuronal cultures to an external electric stimulation for a gradually weaker connectivity strength between neurons, and in cultures with different spatial configurations. The model can be analytically solved in the metric-free, mean-field scenario. The presence of metric correlations precipitates a strong deviation from the mean field. Null models of the same networks that preserve the distribution of connections recover the mean field. Our results show that metric-inherited correlations in spatial networks dominate the connectivity blueprint, mask the actual distribution of connections, and may emerge as the asset that shapes network dynamics.

MeSH terms

  • Cell Culture Techniques
  • Electric Stimulation
  • Models, Neurological*
  • Nerve Net / physiology*
  • Neurons / physiology*