Mycoplasma genitalium Antibiotic Resistance-Mediating Mutations in Canadian Women With or Without Chlamydia Trachomatis Infection

Sex Transm Dis. 2017 Jul;44(7):433-435. doi: 10.1097/OLQ.0000000000000617.

Abstract

Testing remnant Aptima specimens from women infected with Chlamydia trachomatis detected 13.4% (53/396) with Mycoplasma genitalium compared with 5.4% (22/406) in matched C. trachomatis-negative women. Overall, 9.4% (provincial ranges of 3-20%) were infected with M. genitalium and resistance mediating mutations were found in 47.3% (26/55) to macrolides and 1.9% (1/53) to fluoroquinolones by sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Canada / epidemiology
  • Chlamydia Infections / epidemiology*
  • Chlamydia Infections / microbiology*
  • Chlamydia trachomatis
  • Coinfection
  • Drug Resistance, Bacterial / drug effects*
  • Drug Resistance, Bacterial / genetics*
  • Female
  • Fluoroquinolones / pharmacology
  • Humans
  • Macrolides / pharmacology
  • Middle Aged
  • Multilocus Sequence Typing
  • Mutation
  • Mycoplasma Infections / drug therapy
  • Mycoplasma Infections / epidemiology*
  • Mycoplasma Infections / microbiology*
  • Mycoplasma genitalium / drug effects*
  • Mycoplasma genitalium / genetics*
  • Polymorphism, Single Nucleotide
  • Prevalence
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Macrolides