Metal-Free Oxidative C-C Bond Functionalization of Methylenecyclopropanes with Ethers Leading to 2-Substituted 3,4-Dihydronaphthalenes

J Org Chem. 2017 Jul 21;82(14):7394-7401. doi: 10.1021/acs.joc.7b00970. Epub 2017 Jun 28.

Abstract

A novel metal-free oxidative ring-opening/cyclization of methylenecyclopropanes with ethers was established for the synthesis of diverse 2-substituted 3,4-dihydronaphthalenes with high selectivity and efficiency. This oxidative cyclization is achieved by C(sp3)-H functionalization, ring-opening, and cyclization, and this method represents a new example of methylenecyclopropane oxidative cyclization with an aromatic carbon and a C(sp3)-H bond by simultaneously forming two new carbon-carbon bonds.

Publication types

  • Research Support, Non-U.S. Gov't