Live or Die? Depends on Who You Are

Takaaki Kuwajima; Carol Mason

doi:10.1016/j.neuron.2017.06.016

Live or Die? Depends on Who You Are

Neuron. 2017 Jun 21;94(6):1043-1046. doi: 10.1016/j.neuron.2017.06.016.

Authors

Takaaki Kuwajima¹, Carol Mason²

Affiliations

¹ Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
² Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: cam4@columbia.edu.

PMID: 28641102
DOI: 10.1016/j.neuron.2017.06.016

Abstract

In this issue of Neuron, Welsbie et al. (2017) and Norsworthy et al. (2017) implicate the transcription factor Sox11 as a key player after optic nerve injury-in DLK signaling of RGC cell death, and in RGC regeneration and survival but only in certain RGCs.

Keywords: DLK; PTEN; axon regeneration; cell death; ceramide; retinal ganglion cell.

MeSH terms

Axons*
Cell Death
Cell Survival
Humans
Nerve Regeneration
Optic Nerve
Optic Nerve Injuries
Retinal Ganglion Cells*
Signal Transduction