Unexpected pharmacokinetics of recombinant porcine factor VIII in a patient with acquired factor VIII deficiency and spontaneous epidural haematoma

Haemophilia. 2017 Sep;23(5):e453-e456. doi: 10.1111/hae.13247. Epub 2017 Jun 29.

Authors

J J Shatzel¹, S Azar¹, R Scherber¹, N Gay¹, T G Deloughery^{1

2

3}, A VanSandt^{2

3}, R Kruse-Jarres⁴, M Recht³, J A Taylor^{1

3

5}

Affiliations

¹ Department of Medicine, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR, USA.
² Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
³ The Hemophilia Center at Oregon Health & Science University, Portland, OR, USA.
⁴ Washington Center for Bleeding Disorders at BloodWorks Northwest, University of Washington, Seattle, WA, USA.
⁵ VA Medical Center, Portland, OR, USA.

PMID: 28664642
DOI: 10.1111/hae.13247

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Animals
Factor VIII / pharmacokinetics*
Factor VIII / therapeutic use
Female
Hematoma, Epidural, Spinal / complications*
Hemophilia A / complications*
Hemophilia A / drug therapy*
Hemophilia A / metabolism
Humans
Middle Aged
Recombinant Proteins / pharmacokinetics*
Recombinant Proteins / therapeutic use
Swine

Substances

Recombinant Proteins
Factor VIII

Supplementary concepts

Factor 8 deficiency, acquired