Rhabdomyolysis and AKI with Atorvastatin and Sitagliptin Use in the Setting of Low 25-Hydroxyvitamin D Levels

J Gen Intern Med. 2017 Oct;32(10):1156-1159. doi: 10.1007/s11606-017-4115-x. Epub 2017 Jul 13.

Abstract

We report a case of an 86-year-old woman admitted to the hospital with rhabdomyolysis and acute kidney injury 3 weeks after starting sitagliptin while on long-term atorvastatin therapy. She also had low levels of 25-hydroxyvitamin D and mild chronic kidney disease, which may have contributed to the development of rhabdomyolysis. A review of the literature reveals four previous reports of this drug interaction in elderly patients, some with underlying kidney disease.

Keywords: acute kidney injury; drug interaction; rhabdomyolysis; sitagliptin; statins; vitamin D.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / blood*
  • Acute Kidney Injury / chemically induced
  • Aged, 80 and over
  • Atorvastatin / adverse effects*
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Rhabdomyolysis / blood*
  • Rhabdomyolysis / chemically induced
  • Rhabdomyolysis / diagnosis
  • Sitagliptin Phosphate / adverse effects*
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Vitamin D
  • Atorvastatin
  • 25-hydroxyvitamin D
  • Sitagliptin Phosphate