Amineptine: its effect on the dopaminergic system of rats

J Pharm Pharmacol. 1986 Apr;38(4):301-3. doi: 10.1111/j.2042-7158.1986.tb04572.x.

Abstract

3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents, Tricyclic / pharmacology*
  • Brain Chemistry / drug effects*
  • Corpus Striatum / metabolism
  • Dibenzocycloheptenes / pharmacology*
  • Dopamine / analogs & derivatives
  • Dopamine / metabolism*
  • Hydrazines / pharmacology
  • Levodopa / metabolism
  • Limbic System / metabolism
  • Male
  • Pargyline / pharmacology
  • Rats

Substances

  • Antidepressive Agents, Tricyclic
  • Dibenzocycloheptenes
  • Hydrazines
  • amineptin
  • Levodopa
  • Pargyline
  • 3-hydroxybenzylhydrazine
  • 3-methoxytyramine
  • Dopamine