Abstract
Primary superior vena cava lymphoma originating from the endothelium of a large vein is very rare. A 70-year-old man was admitted to the hospital; computed tomography showed a tumor limited to the inside of the superior vena cava, completely occluding the vessel. A transjugular biopsy confirmed the diagnosis of diffuse large B-cell lymphoma, which was diffusely positive for CD30. Rituximab monotherapy followed by five courses of R-CHOP chemotherapy induced a complete remission. There was no recurrence after two years. The pathophysiology of lymphoma derived from large vessels may be different from intravascular large B-cell lymphoma, which usually involves small vessels.
Keywords:
CD30; intravascular lymphoma; malignant lymphoma; superior vena cava syndrome.
MeSH terms
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Aged
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Antibodies, Monoclonal, Murine-Derived / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biopsy
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Humans
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Ki-1 Antigen / analysis
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Lymphoma, Large B-Cell, Diffuse / complications
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Lymphoma, Large B-Cell, Diffuse / diagnostic imaging*
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Lymphoma, Large B-Cell, Diffuse / pathology
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Male
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Neoplasm Recurrence, Local / drug therapy
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Prednisone / therapeutic use
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Remission Induction
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Rituximab
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Superior Vena Cava Syndrome / etiology
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Tomography, X-Ray Computed
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Vena Cava, Superior*
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Vincristine / therapeutic use
Substances
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Antibodies, Monoclonal, Murine-Derived
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Ki-1 Antigen
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R-CHOP protocol
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone