[Lymphocyte-depleted classical Hodgkin lymphoma accompanied by myelofibrosis]

Rinsho Ketsueki. 2017;58(7):772-775. doi: 10.11406/rinketsu.58.772.
[Article in Japanese]

Abstract

A 91-year-old male with fever of unknown origin was referred to our department. 18F-FDG PET/CT scan revealed a high FDG uptake in abdominal lymph nodes and multiple bones. The bone marrow biopsy showed fibrosis and atypical megakaryocytes, which were consistent with myelofibrosis. The patient died 28 days after admission and an autopsy was performed. The lymph nodes and bone marrow specimens revealed scattered Reed-Sternberg cells and a dearth of lymphoid cells with fibrosis. A final diagnosis of lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) with bone marrow involvement was made. It is necessary to identify LDCHL during differential diagnosis for bone marrow fibrosis accompanied by lymphadenopathy.

Keywords: Bone marrow involvement; Lymphocyte-depleted classical Hodgkin lymphoma; Myelofibrosis.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Autopsy
  • Fatal Outcome
  • Hodgkin Disease / complications
  • Hodgkin Disease / diagnosis*
  • Hodgkin Disease / pathology*
  • Humans
  • Male
  • Neoplasm Invasiveness
  • Primary Myelofibrosis / diagnosis*
  • Primary Myelofibrosis / etiology
  • Primary Myelofibrosis / pathology*