Different toxicity of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on the nigrostriatal and mesolimbic pathways

Eur J Pharmacol. 1987 Jan 13;133(2):239-41. doi: 10.1016/0014-2999(87)90156-7.

Abstract

The influence of MPTP (30 mg/kg X 2) on dopamine content and tyrosine hydroxylase activity in striatal, limbic and cortical areas of C-57/B16 mice was studied. General dopamine depletion was observed 24 h after the treatment, but 30 days after administration recovery was complete in all but the striatum. At 24 h, tyrosine hydroxylase activity was decreased only in striatum. It is proposed that MPTP acts differently in striatum and in other dopaminergic areas.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Cerebral Cortex / drug effects
  • Corpus Striatum / drug effects
  • Dopamine / metabolism*
  • Limbic System / drug effects
  • Mice
  • Mice, Inbred C57BL
  • Neural Pathways / drug effects
  • Pyridines / toxicity*
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Pyridines
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Tyrosine 3-Monooxygenase
  • Dopamine