Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Yoshihiro Kokubo; Isao Saito; Hiroyasu Iso; Kazumasa Yamagishi; Hiroshi Yatsuya; Junko Ishihara; Koutatsu Maruyama; Manami Inoue; Norie Sawada; Shoichiro Tsugane; JPHC Study Group

doi:10.1016/j.clnu.2017.08.006

Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Clin Nutr. 2018 Oct;37(5):1602-1608. doi: 10.1016/j.clnu.2017.08.006. Epub 2017 Aug 12.

Authors

Collaborators

JPHC Study Group:
S Tsugane¹⁰, N Sawada¹⁰, M Iwasaki¹⁰, S Sasazuki¹⁰, T Yamaji¹⁰, T Shimazu¹⁰, T Hanaoka¹⁰, J Ogata¹¹, S Baba¹¹, T Mannami¹¹, A Okayama¹¹, Y Kokubo¹¹, K Miyakawa¹², F Saito¹², A Koizumi¹², Y Sano¹², I Hashimoto¹², T Ikuta¹², Y Tanaba¹², H Sato¹², Y Roppongi¹², T Takashima¹², H Suzuki¹², Y Miyajima¹³, N Suzuki¹³, S Nagasawa¹³, Y Furusugi¹³, N Nagai¹³, Y Ito¹³, S Komatsu¹³, T Minamizono¹³, H Sanada¹⁴, Y Hatayama¹⁴, F Kobayashi¹⁴, H Uchino¹⁴, Y Shirai¹⁴, T Kondo¹⁴, R Sasaki¹⁴, Y Watanabe¹⁴, Y Miyagawa¹⁴, Y Kobayashi¹⁴, M Machida¹⁴, K Kobayashi¹⁴, M Tsukada¹⁴, Y Kishimoto¹⁵, E Takara¹⁵, T Fukuyama¹⁵, M Kinjo¹⁵, M Irei¹⁵, H Sakiyama¹⁶, K Imoto¹⁷, H Yazawa¹⁷, T Seo¹⁷, A Seiko¹⁷, F Ito¹⁷, F Shoji¹⁷, R Saito¹⁷, A Murata¹⁸, K Minato¹⁸, K Motegi¹⁸, T Fujieda¹⁸, S Yamato¹⁸, K Matsui¹⁹, T Abe¹⁹, M Katagiri¹⁹, M Suzuki¹⁹, M Doi²⁰, A Terao²⁰, Y Ishikawa²⁰, T Tagami²⁰, H Sueta²¹, H Doi²¹, M Urata²¹, N Okamoto²¹, F Ide²¹, H Goto²¹, R Fujita²¹, N Onga²², H Takaesu²², M Uehara²², T Nakasone²², M Yamakawa²², F Horii²³, I Asano²³, H Yamaguchi²³, K Aoki²³, S Maruyama²³, M Ichii²³, M Takano²³, Y Tsubono²⁴, K Suzuki²⁵, Y Honda²⁶, K Yamagishi²⁶, S Sakurai²⁶, N Tsuchiya²⁶, M Kabuto²⁷, M Yamaguchi²⁸, Y Matsumura²⁸, S Sasaki²⁸, S Watanabe²⁸, M Akabane²⁹, T Kadowaki³⁰, M Inoue³⁰, M Noda³¹, T Mizoue³¹, Y Kawaguchi³², Y Takashima³³, Y Yoshida³³, K Nakamura³⁴, R Takachi³⁴, J Ishihara³⁵, S Matsushima³⁶, S Natsukawa³⁶, H Shimizu³⁷, H Sugimura³⁸, S Tominaga³⁹, N Hamajima⁴⁰, H Iso⁴¹, T Sobue⁴¹, M Iida⁴², W Ajiki⁴², A Ioka⁴², S Sato⁴³, E Maruyama⁴⁴, M Konishi⁴⁵, K Okada⁴⁵, I Saito⁴⁵, N Yasuda⁴⁶, S Kono⁴⁷, S Akiba⁴⁸, T Isobe⁴⁹

Affiliations

¹ Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: ykokubo@hsp.ncvc.go.jp.
² Department of Public Health, Ehime University Graduate School of Medicine, Toon, Japan.
³ Department of Public Health, Social Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
⁴ Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
⁵ Department of Public Health, School of Medicine, Fujita Health University, Nagoya, Japan.
⁶ Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan; Department of Food and Life Science, School of Life and Environmental Science, Azabu University, Sagamihara City, Japan.
⁷ Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
⁸ Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan; Department of Global Health Policy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
⁹ Department of Global Health Policy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
¹⁰ National Cancer Center, Tokyo, Japan.
¹¹ National Cerebral and Cardiovascular Center, Osaka, Japan.
¹² Iwate Prefectural Ninohe Public Health Center, Iwate, Japan.
¹³ Akita Prefectural Yokote Public Health Center, Akita, Japan.
¹⁴ Nagano Prefectural Saku Public Health Center, Nagano, Japan.
¹⁵ Okinawa Prefectural Chubu Public Health Center, Okinawa, Japan.
¹⁶ Okinawa Prefectural Chubu Public Health Center, Okinawa, Japan; Okinawa Prefectural Miyako Public Health Center, Okinawa, Japan.
¹⁷ Katsushika Public Health Center, Tokyo, Japan.
¹⁸ Ibaraki Prefectural Mito Public Health Center, Ibaraki, Japan.
¹⁹ Niigata Prefectural Kashiwazaki and Nagaoka Public Health Center, Niigata, Japan.
²⁰ Kochi Prefectural Chuo-higashi Public Health Center, Kochi, Japan.
²¹ Nagasaki Prefectural Kamigoto Public Health Center, Nagasaki, Japan.
²² Okinawa Prefectural Miyako Public Health Center, Okinawa, Japan.
²³ Osaka Prefectural Suita Public Health Center, Osaka, Japan.
²⁴ Tohoku University, Miyagi, Japan.
²⁵ Research Institute for Brain and Blood Vessels Akita, Akita, Japan.
²⁶ University of Tsukuba, Ibaraki, Japan.
²⁷ National Institute for Environmental Studies, Ibaraki, Japan.
²⁸ National Institute of Health and Nutrition, Tokyo, Japan.
²⁹ Tokyo University of Agriculture, Tokyo, Japan.
³⁰ The University of Tokyo, Tokyo, Japan.
³¹ National Center for Global Health and Medicine, Tokyo, Japan.
³² Tokyo Medical and Dental University, Tokyo, Japan.
³³ Kyorin University, Tokyo, Japan.
³⁴ Niigata University, Niigata, Japan.
³⁵ Sagami Women's University, Kanagawa, Japan.
³⁶ Saku General Hospital, Nagano, Japan.
³⁷ Sakihae Institute, Gifu, Japan.
³⁸ Hamamatsu University School of Medicine, Shizuoka, Japan.
³⁹ Aichi Cancer Center, Aichi, Japan.
⁴⁰ Nagoya University, Aichi, Japan.
⁴¹ Osaka University, Osaka, Japan.
⁴² Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan.
⁴³ Chiba Prefectural Institute of Public Health, Chiba, Japan.
⁴⁴ Kobe University, Hyogo, Japan.
⁴⁵ Ehime University, Ehime, Japan.
⁴⁶ Kochi University, Kochi, Japan.
⁴⁷ Kyushu University, Fukuoka, Japan.
⁴⁸ Kagoshima University, Kagoshima, Japan.
⁴⁹ Tokyo Gakugei University, Japan.

PMID: 28843443
DOI: 10.1016/j.clnu.2017.08.006

Abstract

Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population.

Subjects/methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45-74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire.

Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50-0.99) and 0.66 (0.44-0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39-0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes.

Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

Keywords: Coronary heart disease; Dietary magnesium; Population study; Prospective study; Stroke.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cohort Studies
Coronary Disease / epidemiology*
Coronary Disease / prevention & control
Diet Records
Diet*
Female
Humans
Japan / epidemiology
Magnesium / administration & dosage*
Male
Middle Aged
Prospective Studies
Risk Factors
Stroke / epidemiology
Stroke / prevention & control
Surveys and Questionnaires

Substances

Magnesium