No. 247-Antibiotic Prophylaxis in Obstetric Procedures

Abstract

Objective: To review the evidence and provide recommendations on antibiotic prophylaxis for obstetrical procedures.

Outcomes: Outcomes evaluated include need and effectiveness of antibiotics to prevent infections in obstetrical procedures.

Evidence: Published literature was retrieved through searches of Medline and The Cochrane Library on the topic of antibiotic prophylaxis in obstetrical procedures. Results were restricted to systematic reviews, randomized controlled trials/controlled clinical trials, and observational studies. Searches were updated on a regular basis and articles published from January 1978 to June2009 were incorporated in the guideline. Current guidelines published by the American College of Obstetrics and Gynecology were also incorporated. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.

Values: The evidence obtained was reviewed and evaluated by the Infectious Diseases Committee of the Society of Obstetricians and Gynaecologists of Canada under the leadership of the principal authors, and recommendations were made according to guidelines developed by the Canadian Task Force on Preventive Health Care (Table 1).

Benefits, harms, and costs: Implementation of this guideline should reduce the cost and harm resulting from the administration of antibiotics when they are not required and the harm resulting from failure to administer antibiotics when they would be beneficial.

Summary statements: RECOMMENDATIONS.

Keywords: Antibiotic prophylaxis; SSI; endocarditis; endometritis; obstetrical procedures; surgical prophylaxis; surgical site infection.