Genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies

Muscle Nerve. 2018 Jan;57(1):6-15. doi: 10.1002/mus.25953. Epub 2017 Sep 22.

Abstract

Muscular dystrophy is defined as the progressive wasting of skeletal muscles that is caused by inherited or spontaneous genetic mutations. Next-generation sequencing has greatly improved the accuracy and speed of diagnosis for different types of muscular dystrophy. Advancements in depth of coverage, convenience, and overall reduced cost have led to the identification of genetic modifiers that are responsible for phenotypic variability in affected patients. These genetic modifiers have been postulated to explain key differences in disease phenotypes, including age of loss of ambulation, steroid responsiveness, and the presence or absence of cardiac defects in patients with the same form of muscular dystrophy. This review highlights recent findings on genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies based on animal and clinical studies. These genetic modifiers hold great promise to be developed into novel therapeutic targets for the treatment of muscular dystrophies. Muscle Nerve 57: 6-15, 2018.

Keywords: DMD; genetic modifier; muscle disease; muscular dystrophy; variant.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Genetic Therapy
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Muscular Dystrophy, Duchenne / drug therapy
  • Muscular Dystrophy, Duchenne / genetics*
  • Muscular Dystrophy, Duchenne / physiopathology
  • Muscular Dystrophy, Facioscapulohumeral / drug therapy
  • Muscular Dystrophy, Facioscapulohumeral / genetics*
  • Muscular Dystrophy, Facioscapulohumeral / physiopathology