The TREX1 Dinosaur Bites the Brain through the LINE

José Luis García Pérez; Marta E Alarcón-Riquelme

doi:10.1016/j.stem.2017.08.010

The TREX1 Dinosaur Bites the Brain through the LINE

Cell Stem Cell. 2017 Sep 7;21(3):287-288. doi: 10.1016/j.stem.2017.08.010.

Authors

José Luis García Pérez¹, Marta E Alarcón-Riquelme²

Affiliations

¹ Pfizer - University of Granada - Andalusian Government Center for Genomics and Oncological Research (GENYO), PTS, 18016, Granada, Spain; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
² Pfizer - University of Granada - Andalusian Government Center for Genomics and Oncological Research (GENYO), PTS, 18016, Granada, Spain; Unit for Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institute, Solna, 171 77, Sweden. Electronic address: marta.alarcon@genyo.es.

PMID: 28886359
DOI: 10.1016/j.stem.2017.08.010

Abstract

In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.

Publication types

Comment

MeSH terms

Animals
Autoimmune Diseases of the Nervous System / genetics*
Autoimmune Diseases*
Brain
Dinosaurs*
Humans
Phosphoproteins / genetics
Stem Cells

Substances

Phosphoproteins