Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major

Phillip Wong; Frances Milat; Peter J Fuller; Peter G Kerr; James C G Doery; Danielle H Oh; Dana Jackson; Matthew T Gillespie; Donald K Bowden; Sant-Rayn Pasricha; Ken K Lau

doi:10.1111/imj.13533

Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major

Intern Med J. 2017 Sep;47(9):1064-1067. doi: 10.1111/imj.13533.

Authors

Phillip Wong^{1

2

3}, Frances Milat^{1

2

3}, Peter J Fuller^{1

2

3

4}, Peter G Kerr⁵, James C G Doery^{3

6}, Danielle H Oh⁷, Dana Jackson⁸, Matthew T Gillespie^{1

4}, Donald K Bowden⁹, Sant-Rayn Pasricha^{9

10

11}, Ken K Lau^{3

8}

Affiliations

¹ Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
² Department of Endocrinology, Monash Health, Melbourne, Victoria, Australia.
³ Department of Medicine, Monash University, Melbourne, Victoria, Australia.
⁴ Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia.
⁵ Department of Renal Medicine, Monash Health, Melbourne, Victoria, Australia.
⁶ Department of Pathology, Monash Health, Melbourne, Victoria, Australia.
⁷ Department of Haematology, Monash Health, Melbourne, Victoria, Australia.
⁸ Department of Radiology, Monash Health, Melbourne, Victoria, Australia.
⁹ Thalassaemia Service, Monash Health, Melbourne, Victoria, Australia.
¹⁰ Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
¹¹ MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

PMID: 28891172
DOI: 10.1111/imj.13533

Abstract

Asymptomatic urolithiasis is common and of mixed composition in patients with β-thalassaemia major. Twenty-seven subjects were imaged using dual-energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium-containing urolithiasis was associated with reduced femoral neck Z scores.

Keywords: computed tomography; kidney stone; osteoporosis; thalassaemia; urolithiasis.

MeSH terms

Adult
Bone Density / physiology*
Female
Humans
Hypercalcemia / diagnostic imaging
Hypercalcemia / epidemiology*
Hypercalcemia / metabolism
Male
Middle Aged
Prevalence
Urolithiasis / diagnostic imaging
Urolithiasis / epidemiology*
Urolithiasis / metabolism
Young Adult
beta-Thalassemia / diagnostic imaging
beta-Thalassemia / epidemiology*
beta-Thalassemia / metabolism