The role of oxidative stress in influenza virus infection

Miaomiao Liu; Fangzhao Chen; Teng Liu; Feimin Chen; Shuwen Liu; Jie Yang

doi:10.1016/j.micinf.2017.08.008

The role of oxidative stress in influenza virus infection

Microbes Infect. 2017 Dec;19(12):580-586. doi: 10.1016/j.micinf.2017.08.008. Epub 2017 Sep 14.

Authors

Miaomiao Liu¹, Fangzhao Chen¹, Teng Liu¹, Feimin Chen¹, Shuwen Liu¹, Jie Yang²

Affiliations

¹ Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
² Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: yj528@smu.edu.cn.

PMID: 28918004
DOI: 10.1016/j.micinf.2017.08.008

Abstract

Virus-induced oxidative stress plays an important role in the regulation of the host immune system. In this review, we provide backgrounds of the pathogenic mechanism of oxidative stress induced by influenza virus and the specific oxidant-sensitive pathways, and highlight that antioxidant is one of the effective strategies against influenza virus infection.

Keywords: Antioxidants; Influenza virus; Oxidative stress; The immunity system.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / metabolism*
Humans
Hydrogen Peroxide / metabolism
Inflammation / pathology*
Influenza A Virus, H1N1 Subtype / immunology*
Influenza, Human / pathology*
Influenza, Human / virology
Oxidative Stress / immunology*
Oxidative Stress / physiology

Substances

Antioxidants
Hydrogen Peroxide