Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: The multiparametric approach is not convincing
Semin Oncol
.
2017 Apr;44(2):159-160.
doi: 10.1053/j.seminoncol.2017.06.001.
Epub 2017 Jul 4.
Authors
Marie-Christine Etienne-Grimaldi
1
,
Chantal Barin Le Guellec
2
,
Jean-Christophe Boyer
3
,
Etienne Chatelut
4
,
Alexandre Evrard
3
,
Marie-Anne Loriot
5
,
Angelo Paci
6
,
Bernard Royer
7
,
Fabienne Thomas
4
,
Joseph Ciccolini
8
Affiliations
1
Oncopharmacology laboratory, Centre Antoine Lacassagne, Nice, France. Electronic address: marie-christine.etienne@nice.unicancer.fr.
2
Biochemistry laboratory, CHU Tours-Bretonneau, Tours, France.
3
Biochemistry laboratory, CHU Nîmes-Carémeau, Nîmes, France.
4
Laboratoire de Biologie Médicale Oncologique, Institut Claudius-Regaud, CRCT, Toulouse, France.
5
Biochemistry Department, Hopital Européen Georges Pompidou, Paris, France.
6
Department of Clinical Pharmacy, SIPAM, Institut de Cancérologie Gustave Roussy, Villejuif, France.
7
Department of Clinical Pharmacology, CHU Jean Minjoz, Besançon, France.
8
SMARTc, Department of Pharmacokinetics, CHU Timone, Marseille, France.
PMID:
28923215
DOI:
10.1053/j.seminoncol.2017.06.001
No abstract available
Publication types
Letter
Comment
MeSH terms
Dihydropyrimidine Dehydrogenase Deficiency*
Dihydrouracil Dehydrogenase (NADP)
Drug-Related Side Effects and Adverse Reactions*
Fluorouracil
Humans
Substances
Dihydrouracil Dehydrogenase (NADP)
Fluorouracil