Acute exacerbations of COPD: risk factors for failure and relapse

Marco Mantero; Paola Rogliani; Marta Di Pasquale; Eva Polverino; Ernesto Crisafulli; Monica Guerrero; Andrea Gramegna; Mario Cazzola; Francesco Blasi

doi:10.2147/COPD.S145253

Acute exacerbations of COPD: risk factors for failure and relapse

Int J Chron Obstruct Pulmon Dis. 2017 Sep 8:12:2687-2693. doi: 10.2147/COPD.S145253. eCollection 2017.

Authors

Marco Mantero^{1

2}, Paola Rogliani³, Marta Di Pasquale^{1

2}, Eva Polverino⁴, Ernesto Crisafulli⁵, Monica Guerrero⁶, Andrea Gramegna^{1

2}, Mario Cazzola³, Francesco Blasi^{1

2}

Affiliations

¹ Department of Pathophysiology and Transplantation, Università degli Studi di Milano.
² Internal Medicine Department, Respiratory Unit and Regional Adult Cystic Fibrosis Center, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan.
³ Respiratory Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁴ Respiratory Disease Department, Servei de Pneumologia, Hospital Universitari Vall d'Hebron (HUVH), Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain.
⁵ Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy.
⁶ Hospital d'Igualada, Consorci Socisanitari de l'Anoia, Barcelona, Spain.

Abstract

Acute exacerbations are a leading cause of worsening COPD in terms of lung function decline, quality of life, and survival. They also have a relevant economic burden on the health care system. Determining the risk factors for acute exacerbation and early relapse could be a crucial element for a better management of COPD patients. This review analyzes the current knowledge and underlines the main risk factors for recurrent acute exacerbations. Comprehensive evaluation of COPD patients during stable phase and exacerbation could contribute to prevent treatment failure and relapses.

Keywords: COPD; exacerbations; infections; prevention; treatment.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Bacterial Infections / drug therapy
Bacterial Infections / epidemiology
Bacterial Infections / microbiology
Biomarkers / blood
Comorbidity
Disease Progression
Humans
Lung / microbiology
Lung / physiopathology*
Patient Reported Outcome Measures
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive / diagnosis
Pulmonary Disease, Chronic Obstructive / epidemiology*
Pulmonary Disease, Chronic Obstructive / physiopathology
Pulmonary Disease, Chronic Obstructive / therapy
Recurrence
Respiratory Tract Infections / drug therapy
Respiratory Tract Infections / epidemiology
Respiratory Tract Infections / microbiology
Risk Assessment
Risk Factors
Severity of Illness Index
Time Factors
Treatment Failure

Substances

Anti-Bacterial Agents
Biomarkers