From clinical epidemiology to practice recommendations: Knowledge gaps and uncertainty in the management of anal precancers

Nicolas Wentzensen; Megan A Clarke

doi:10.1002/cncr.31033

From clinical epidemiology to practice recommendations: Knowledge gaps and uncertainty in the management of anal precancers

Cancer. 2017 Dec 1;123(23):4530-4534. doi: 10.1002/cncr.31033. Epub 2017 Sep 26.

Authors

Nicolas Wentzensen¹, Megan A Clarke¹

Affiliation

¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Abstract

We discuss the existing data on anal precancers and demonstrate the impact of evidence gaps and uncertainty on a clinical decision model developed to provide clinical guidance for management of anal precancers.

Keywords: Anal precancer; clinical epidemiology; clinical recommendations; cost effectiveness; uncertainty.

Publication types

Editorial
Research Support, N.I.H., Intramural
Comment

MeSH terms

Cost-Benefit Analysis
HIV
Homosexuality, Male
Humans
Male
Precancerous Conditions*
Sexual and Gender Minorities*
Treatment Outcome
Uncertainty

Grants and funding

ZIA CP010124/ImNIH/Intramural NIH HHS/United States