nNOS uncoupling by oxidized LDL: Implications in atherosclerosis

Juliana Maria Navia-Pelaez; Gianne Paul Campos-Mota; Jessica Cristina Araujo de Souza; Edenil Costa Aguilar; Nikos Stergiopulos; Jacqueline Isaura Alvarez-Leite; Luciano Santos Aggum Capettini

doi:10.1016/j.freeradbiomed.2017.09.018

nNOS uncoupling by oxidized LDL: Implications in atherosclerosis

Free Radic Biol Med. 2017 Dec:113:335-346. doi: 10.1016/j.freeradbiomed.2017.09.018. Epub 2017 Sep 29.

Authors

Juliana Maria Navia-Pelaez¹, Gianne Paul Campos-Mota², Jessica Cristina Araujo de Souza³, Edenil Costa Aguilar⁴, Nikos Stergiopulos⁵, Jacqueline Isaura Alvarez-Leite⁶, Luciano Santos Aggum Capettini⁷

Affiliations

¹ Laboratory of Vascular Biology, Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: julianamaria.navia@gmail.com.
² Laboratory of Vascular Biology, Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: giannepcampos@gmail.com.
³ Laboratory of Vascular Biology, Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: je.araujo12@hotmail.com.
⁴ Laboratory of Vascular Biology, Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil; Laboratory of Atherosclerosis and Nutritional Biochemistry, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: edenilaguilar@gmail.com.
⁵ Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, BM 5128 Station 17, CH-1015 Lausanne, Switzerland. Electronic address: nikolaos.stergiopulos@epfl.ch.
⁶ Laboratory of Atherosclerosis and Nutritional Biochemistry, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: jalvarezleite@gmail.com.
⁷ Laboratory of Vascular Biology, Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: capettini@icb.ufmg.br.

PMID: 28970060
DOI: 10.1016/j.freeradbiomed.2017.09.018

No abstract available

MeSH terms

Animals
Atherosclerosis / enzymology
Atherosclerosis / metabolism*
Atherosclerosis / pathology
Cell Line
Disease Models, Animal
Endothelium / enzymology
Endothelium / metabolism*
Endothelium / pathology
Humans
Inflammation
Lipoproteins, LDL*
Mice
Mice, Inbred C57BL
Mice, Knockout
Nitric Oxide Synthase Type I / metabolism*
Oxidative Stress*
Signal Transduction

Substances

Lipoproteins, LDL
oxidized low density lipoprotein
Nitric Oxide Synthase Type I