The fractional catabolic rate of low density lipoprotein in normal individuals is influenced by variation in the apolipoprotein B gene: a preliminary study

Atherosclerosis. 1988 May;71(1):81-5. doi: 10.1016/0021-9150(88)90305-x.

Abstract

In a random sample of 22 normolipidaemic male Caucasian individuals, 35-49 years old, homozygosity for the X2 allele (cutting site) of the XbaI RFLP of the apo B gene was associated with higher mean total cholesterol and LDL-cholesterol concentration. These individuals also had significantly lower LDL fractional catabolic rate (P less than 0.03) and a lower degradation of LDL by mononuclear cells in vitro. We propose that the XbaI polymorphism is associated with amino acid changes in the apo B protein which influences LDL binding to the LDL-receptor. This modulates catabolism of this lipoprotein and so contributes to variability of plasma cholesterol levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apolipoproteins B / genetics*
  • Genes*
  • Genetic Variation*
  • Homozygote
  • Humans
  • Lipoproteins, LDL / metabolism*
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length
  • Receptors, LDL / genetics

Substances

  • Apolipoproteins B
  • Lipoproteins, LDL
  • Receptors, LDL