Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Cell Cycle. 2017;16(24):2323-2325. doi: 10.1080/15384101.2017.1387698. Epub 2017 Dec 6.

Abstract

Chromosome instability (CIN) contributes to the development of many cancer. In this paper, we summarize our recent finding that a novel pathway by which FBW7 loss promotes Centromere Protein A (CENP-A) phosphorylation on Serine 18 through Cyclin E1/CDK2, therefore promoting CIN and tumorigenesis. Our finding demonstrates the importance of CENP-A post-translational modification on modulating centromere and mitotic functions in cancer.

Keywords: CENP-A; Cyclin E1; FBW7; centromere; chromosome instability; tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carcinogenesis
  • Centromere Protein A / genetics
  • Centromere Protein A / metabolism*
  • Chromosomal Instability*
  • DNA-Binding Proteins / metabolism
  • F-Box-WD Repeat-Containing Protein 7 / metabolism
  • Humans
  • Mutagenesis, Site-Directed
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Phosphorylation

Substances

  • Centromere Protein A
  • DNA-Binding Proteins
  • F-Box-WD Repeat-Containing Protein 7
  • FBXW7 protein, human
  • HJURP protein, human