Shigella Stays on the Move

Cell Host Microbe. 2017 Oct 11;22(4):432-433. doi: 10.1016/j.chom.2017.09.013.

Abstract

Guanylate-binding proteins (GBPs) confer protection against intracellular pathogens. In this issue of Cell Host & Microbe, Wandel et al. (2017) report that cytosolic Shigella becomes trapped within a GBP coat that prevents bacterial cell-to-cell spread. However, this defense mechanism is counteracted by the bacterial E3 ubiquitin ligase IpaH9.8.

Publication types

  • Comment

MeSH terms

  • Carrier Proteins
  • Humans
  • Shigella*
  • Ubiquitin-Protein Ligases*

Substances

  • Carrier Proteins
  • Ubiquitin-Protein Ligases