1 Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine-Section on Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland.