Denosumab-induced cutaneous hypersensitivity reaction with distinct clinical and histopathologic findings

Brian J King; Julia S Lehman; Julio C Sartori Valinotti

doi:10.1111/cup.13070

Denosumab-induced cutaneous hypersensitivity reaction with distinct clinical and histopathologic findings

J Cutan Pathol. 2018 Feb;45(2):156-158. doi: 10.1111/cup.13070. Epub 2017 Nov 27.

Authors

Brian J King¹, Julia S Lehman^{1

2}, Julio C Sartori Valinotti¹

Affiliations

¹ Department of Dermatology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota.
² Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota.

PMID: 29076163
DOI: 10.1111/cup.13070

Abstract

Cutaneous reactions from targeted biologics are increasingly common. We describe a case of a cutaneous lichenoid drug eruption from the RANK inhibitor denosumab and a previously unreported lymphohistiocytic reaction pattern. The clinical and histopathological details of this case will aid in recognition, diagnosis, and treatment of drug rashes from denosumab.

Keywords: cutaneous hypersensitivity; dermatopathology; drug eruption.

Publication types

Case Reports

MeSH terms

Aged
Bone Density Conservation Agents / adverse effects*
Denosumab / adverse effects*
Drug Eruptions / pathology*
Female
Humans
Lichenoid Eruptions / chemically induced
Lichenoid Eruptions / pathology
Osteoporosis / drug therapy

Substances

Bone Density Conservation Agents
Denosumab