Oseltamivir (Tamiflu)-induced Bilateral Ciliochoroidal Effusion and Angle Closure Glaucoma: What Type of Idiosyncratic Reaction?

Shahin Yazdani; Hamed Esfandiari; Sare Safi; Alireza Fatemi

doi:10.4103/jovr.jovr_200_15

Oseltamivir (Tamiflu)-induced Bilateral Ciliochoroidal Effusion and Angle Closure Glaucoma: What Type of Idiosyncratic Reaction?

J Ophthalmic Vis Res. 2017 Oct-Dec;12(4):434-436. doi: 10.4103/jovr.jovr_200_15.

Authors

Shahin Yazdani^{1

2}, Hamed Esfandiari², Sare Safi², Alireza Fatemi³

Affiliations

¹ Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Purpose: To report a case of bilateral acute angle closure glaucoma after one dose of oseltamivir 75 mg.

Case report: A 37-year-old man with a history of influenza developed high intraocular pressure and uniformly shallow anterior chamber in both eyes, 5 hours after the first dose of oseltamivir 75 mg. The condition was managed successfully with topical cycloplegic and systemic/topical antiglaucoma medications.

Conclusion: Since a presumed idiosyncratic reaction developed right after the first dose of the medication, it challenges the common concept of adaptive immune system involvement in this type of reaction in medication-related ciliochoroidal effusion.

Keywords: Ciliochoroidal Effusion; Idiosyncratic Reaction; Oseltamivir.

Publication types

Case Reports