Anti-HIV Passive Immunization: New Weapons in the Arsenal

Trends Microbiol. 2017 Dec;25(12):954-956. doi: 10.1016/j.tim.2017.10.006. Epub 2017 Oct 30.

Abstract

Anti-HIV passive immunization with human neutralizing monoclonal antibodies (nmAbs) has made exciting gains: (i) identification of the HIV envelope V2 apex as a new in vivo protective epitope, (ii) a novel clade C SHIV for challenge studies, and (iii) a highly protective, trispecific nmAb. Potent, broad-spectrum protection by nmAbs holds promise.

Keywords: broadly neutralizing monoclonal antibody; clade C SHIV; nonhuman primate models; passive immunization; trispecific neutralizing monoclonal antibody.

Publication types

  • Comment

MeSH terms

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing*
  • HIV-1 / immunology*
  • Humans
  • Immunization, Passive
  • Neutralization Tests
  • Weapons

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing