Targeting the Lysosome for Cancer Therapy

Cancer Discov. 2017 Nov;7(11):1218-1220. doi: 10.1158/2159-8290.CD-17-0996.

Abstract

<b/> Lysosomes are the recycling centers of the cell where organelles and proteins are degraded during autophagy and macropinocytosis; they also serve as signaling hubs that control the activity of mTORC1. In this issue, Rebecca and colleagues report the development of a new type of lysosomal inhibitor for cancer therapy that can inhibit multiple lysosomal activities that are needed for tumor cell survival and growth. Cancer Discov; 7(11); 1218-20. ©2017 AACRSee related article by Rebecca et al., p. 1266.

Publication types

  • Comment

MeSH terms

  • Autophagy / drug effects*
  • Autophagy / genetics
  • Humans
  • Lysosomes / drug effects*
  • Lysosomes / genetics
  • Mechanistic Target of Rapamycin Complex 1 / antagonists & inhibitors
  • Mechanistic Target of Rapamycin Complex 1 / genetics*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Signal Transduction / genetics

Substances

  • Mechanistic Target of Rapamycin Complex 1