Teaching an old pathway new tricks: Targeting BTK to block NLRP3

Sci Immunol. 2017 Nov 3;2(17):eaar2548. doi: 10.1126/sciimmunol.aar2548.

Abstract

A proteomics screen identified BTK as a novel inflammasome regulator and demonstrated that blocking BTK can inhibit inflammasome activity.

Publication types

  • Comment

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Carrier Proteins
  • Humans
  • Inflammasomes*
  • NLR Family, Pyrin Domain-Containing 3 Protein*
  • Pyrin Domain

Substances

  • Carrier Proteins
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Agammaglobulinaemia Tyrosine Kinase