Phytoformulation of Sassurea lappa plant extract: A Single blind, noninvasive and split face study of cream on various skin parameters

Pak J Pharm Sci. 2017 Sep;30(5(Supplementary)):1981-1986.

Abstract

Saussurea lappa (SL) has been reported for its antioxidant and anti-ageing properties. Due to this reason it can be incorporated in a stable phytoformulations for cosmetic use. The objective of the study was to evaluate the anti-aging potential of cosmetic o/w emulsion containing the botanical extract of SL. An emulsion (o/w) was prepared using TEGO® Care 450 (Polyglceryl-3-Methyl Glucose Distearate) emulsifier and final emulsion was loaded with 4 % extract of SL in aqueous phase. This emulsion evaluated for its antioxidant and anti-ageing properties on healthy human subjects using a non-invasive technique called surface evaluation of living skin (SELS). The formulation containing SL extract showed significant (p<0.05) changes in Skin roughness (SEr) as -3.13%, -6.26%, -9.39%; Skin Scaliness (SEsc) as - 4.19%, -8.39%, -12.58%; Skin wrinkles (SEw) as -0.5%, -1.08%, -1.63%; and Skin smoothness (SEsm) as 3.28%, 6.57%, 9.85%, respectively, after 30, 60 and 90 days of continous use. Topical application of the cosmetic cream containing SL extract exerts have a significant anti-aging effects, perhaps due to the presence of Kaempferol, gallic acid, Caffeic acid and other essential phenolics.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Emulsifying Agents / administration & dosage*
  • Emulsifying Agents / adverse effects
  • Emulsions
  • Humans
  • Male
  • Pakistan
  • Phytochemicals / administration & dosage*
  • Phytochemicals / adverse effects
  • Plant Extracts / administration & dosage*
  • Plant Extracts / adverse effects
  • Plant Extracts / isolation & purification
  • Plant Roots / chemistry
  • Saussurea / chemistry*
  • Single-Blind Method
  • Skin / drug effects*
  • Skin / pathology
  • Skin Aging / drug effects*
  • Skin Cream / administration & dosage*
  • Skin Cream / adverse effects
  • Stearates / administration & dosage*
  • Stearates / adverse effects
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Emulsifying Agents
  • Emulsions
  • Phytochemicals
  • Plant Extracts
  • Stearates
  • polyglyceryl-3-methylglucose-distearate